Methylamine → HCID 54475508, compound

HRID 427460Notes

Reaction equation

HRID 427460 reaction equation
C[O-].[Na+].[N:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:26]=[CH:25][C:19]([C:20]([O:22]CC)=O)=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[CH3:27][NH2:28]>CO.C(O)C>[CH3:27][NH:28][C:20]([C:19]1[CH:18]=[CH:17][C:16]([N:13]2[CH2:12][CH2:11][N:10]([C:7]3[CH:8]=[CH:9][N:4]=[CH:5][CH:6]=3)[CH2:15][CH2:14]2)=[CH:26][CH:25]=1)=[O:22]

Participants

6

Reactant 3

HCID 6329MethylamineHCID 10942334Sodium MethoxideHCID 18357051HCID 18357051, compound

Product 1

HCID 54475508HCID 54475508, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

A 2M solution of sodium methoxide in methanol (0.89 ml) was added to a suspension of ethyl 4-[4-(4-pyridyl)-1-piperazinyl]benzoate (500 mg) in a 33% solution of monomethylamine in ethanol (15 ml). The mixture was stirred at 40° C. for 18 hours. The mixture was cooled and the solid was collected by filtration. The solid was washed with ethanol and ether to give 1-(4-methylcarbamoylphenyl)-4-(4-pyridyl) piperazine (374 mg) as a cream solid, mp 239-242° C.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationthe solid was collected by filtration
  3. washThe solid was washed with ethanol and ether

Sources & evidence

ORD record
ord-69dcc62ba1e3477697380a71faca60a0
Source dataset
uspto-grants-2001_11
Patent number
US06313127B1

Reaction notes

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