反应详情

2,3-dimethyl-8-(2-(2-(benzyloxy)ethyl)-6-methylbenzylamino)-imidazo[1,2-a]pyridine-6-carboxamide (0.13 g, 0.29 mmol), cyclohexene (1 ml), Pd(OH)2 cat. (25 mg) were added to ethanol (5 ml) and the mixture was refluxed overnight. An additional amount of cyclohexene (1 ml) and Pd(OH)2 cat. (25 mg) were added and the mixture was refluxed for 4 h. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel using methylene chloride:methanol (9:1) as eluent. Treating the residue with chloroform and filtration gave 0.1 g (99%) of the title compound.

1. temperaturethe mixture was refluxed overnight
2. addition(25 mg) were added
3. temperaturethe mixture was refluxed for 4 h
4. customThe solvent was evaporated under reduced pressure
5. customthe residue was purified by column chromatography on silica gel
6. additionTreating the residue
7. filtrationwith chloroform and filtration