反应详情

Using the procedure described in Example 68, Part A, 2-amino-5-(tert-butyldimethylsilyloxy)-N-(4-methoxyphenyl)benzamide (460 mg, 1.23 mmol) was reacted with 4-tert-butylbenzoyl chloride (0.243 mL, 1.24 mmol) in N,N-dimethylformamide (10 mL). After quenching the reaction with saturated aqueous sodium carbonate, the resulting precipitate was filtered and washed with 2:1 diethyl ether/hexane. The solid was vacuum dried at 85° C./0.1 mm for 14 h to give 553 mg (84%) of the title compound as a white solid; mp 207° C.

1. customAfter quenching
2. customthe reaction with saturated aqueous sodium carbonate
3. filtrationthe resulting precipitate was filtered
4. washwashed with 2:1 diethyl ether/hexane
5. customdried at 85° C./0.1 mm for 14 h