反应详情

To a stirred suspension of 2-methyl-5-nitrophenol (2.0 g, 13 mmol) and sodium carbonate (1.94 g, 18.3 mmol) in acetone was added benzyl bromide (1.7 mL, 14 mmol). The mixture was heated to reflux for 24 h, cooled, filtered, and the solid washed with acetone. The filtrate and acetone washings were combined and concentrated in vacuo. Recrystallization from ether/hexanes gave 1.06 g (33%) of the title product as an off-white solid. MS-FD 243 m/e (M+).

1. temperatureThe mixture was heated
2. temperatureto reflux for 24 h
3. temperaturecooled
4. filtrationfiltered
5. washthe solid washed with acetone
6. concentrationconcentrated in vacuo
7. customRecrystallization from ether/hexanes