4-tert-Butylbenzoyl chloride → 2-[(4-tert-Butylbenzoyl)amino]-N-(4-methoxyphenyl)-6-fluorobenzamide

HRID 427636Notes

Reaction equation

HRID 427636 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:19])[C:11]2[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=2[NH2:18])=[CH:5][CH:4]=1.[C:20]([C:24]1[CH:32]=[CH:31][C:27]([C:28](Cl)=[O:29])=[CH:26][CH:25]=1)([CH3:23])([CH3:22])[CH3:21]>>[C:20]([C:24]1[CH:25]=[CH:26][C:27]([C:28]([NH:18][C:12]2[CH:13]=[CH:14][CH:15]=[C:16]([F:17])[C:11]=2[C:10]([NH:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[O:19])=[O:29])=[CH:31][CH:32]=1)([CH3:23])([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 743724-tert-Butylbenzoyl chlorideHCID 18174595N-(4-methoxyphenyl)-2-amino-6-fluorobenzamide

Product 1

HCID 181744192-[(4-tert-Butylbenzoyl)amino]-N-(4-methoxyphenyl)-6-fluorobenzamideYield 66.3%

Procedure

Using the procedure described in Example 93, Part A, N-(4-methoxyphenyl)-2-amino-6-fluorobenzamide (1.9 mmol) and 4-tert-butylbenzoyl chloride (2.1 mmol) yielded 530 mg (65%) of the title compound.

Sources & evidence

ORD record
ord-425416633d9b4f2fa73b8b51884a9814
Source dataset
uspto-grants-2001_11
Patent number
US06313122B1

Reaction notes

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