HCID 69361075, compound → HCID 86585768, compound

HRID 427702Notes

Reaction equation

HRID 427702 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH:38]=[CH:39][CH:40]=1)[C:12]([NH:14][C:15]1[C:16]([NH:21][C:22]([O:24][CH:25]([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[C:26]2[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=2)=[O:23])=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:13])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH:38]=[CH:39][CH:40]=1)[C:12]([NH:14][C:15]1[C:16]([NH:21][C:22]([O:24][CH:25]([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[C:26]2[CH:27]=[CH:28][N:29]=[CH:30][CH:31]=2)=[O:23])=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:13]

Participants

4

Reactant 1

HCID 69361075HCID 69361075, compound

Product 1

HCID 86585768HCID 86585768, compoundYield 48%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of N1-(3-benzyloxybenzoyl)-N2-[1-(4-pyridyl)piperidin-4-ylmethoxycarbonyl]-1,2-benzenediamine (75 mg, 0.14 mmol) and 5% palladium-on-carbon (200 mg) in ethanol (4 mL) was placed under an atmosphere of hydrogen (1 atm). After consumption of the starting material, the mixture was filtered through diatomaceous earth and the filtrate concentrated in vacuo yielding 30 mg (48%) of the title compound.

Workup

  1. customAfter consumption of the starting material
  2. filtrationthe mixture was filtered through diatomaceous earth
  3. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-3e1634e247e841c6bcbcfa62b2d699f9
Source dataset
uspto-grants-2001_11
Patent number
US06313122B1

Reaction notes

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