4-Chlorobenzoyl chloride → HCID 131722967, compound

HRID 427704Notes

Reaction equation

HRID 427704 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:10]=[C:11]([NH:16][C:17]([O:19][CH:20]([CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)=[O:18])[C:12]([NH2:15])=[CH:13][CH:14]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:33][C:34]1[CH:42]=[CH:41][C:37]([C:38](Cl)=[O:39])=[CH:36][CH:35]=1>>[Cl:33][C:34]1[CH:42]=[CH:41][C:37]([C:38]([NH:15][C:12]2[C:11]([NH:16][C:17]([O:19][CH:20]([CH:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)[C:21]3[CH:22]=[CH:23][N:24]=[CH:25][CH:26]=3)=[O:18])=[CH:10][C:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])=[CH:14][CH:13]=2)=[O:39])=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 86757563HCID 86757563, compound

Product 1

HCID 131722967HCID 131722967, compoundYield 72.2%

Procedure

Using a similar procedure to that described in Example 48, Part C, N4-(tert-butoxycarbonyl)-N2-[1-(4-pyridyl)piperidin-4-ylmethoxycarbonyl]-1,2,4-benzenetriamine (380 mg, 0.86 mmol) and 4-chlorobenzoyl chloride (0.12 mL, 0.95 mmol) yielded 360 mg (72%) of the title compound.

Sources & evidence

ORD record
ord-4270491fc2874e73938998ce8875b4e2
Source dataset
uspto-grants-2001_11
Patent number
US06313122B1

Reaction notes

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