反应详情

To a solution of the acetylindoline (D11, 1.19 g, 4.9 mmol) in dry pyridine (10 ml) at 0° C. was added trifluoromethanesulphonic anhydride (1.52 g, 5.4 mmol). The mixture was then stirred overnight, while slowly warming to room temperature. The mixture was partially evaporated, the residual liquor was diluted well with water and the precipitate was filtered off. The crude product was dissolved in dichloromethane and the solution was washed with IN hydrochloric acid and brine, dried and evaporated to give the title compound (1.77 g, 96%).

1. customThe mixture was partially evaporated
2. additionthe residual liquor was diluted well with water
3. filtrationthe precipitate was filtered off
4. dissolutionThe crude product was dissolved in dichloromethane
5. washthe solution was washed with IN hydrochloric acid and brine
6. customdried
7. customevaporated