5-Bromoindoline → 5-Bromo-1-[2-(pyridin-2-ylmethyloxy)pyridin-5-ylcarbamoyl]-indoline

HRID 427738Notes

Reaction equation

HRID 427738 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:24])OC2C=CC=CC=2)=[CH:11][N:10]=1.[Br:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][CH2:30][CH2:29]2>>[Br:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[N:31]([C:16](=[O:24])[NH:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)=[N:10][CH:11]=1)[CH2:30][CH2:29]2

Participants

3

Reactant 2

HCID 34115665-BromoindolineHCID 11141770Phenyl N-[2-(pyridin-2-ylmethyloxy)pyridin-5-yl]carbamate

Product 1

HCID 183577235-Bromo-1-[2-(pyridin-2-ylmethyloxy)pyridin-5-ylcarbamoyl]-indoline

Procedure

Phenyl N-[2-(pyridin-2-ylmethyloxy)pyridin-5-yl]carbamate (D3) and 5-bromoindoline were converted into the title compound using a method similar to that of Example 1, m.p. 138-139° C.

Sources & evidence

ORD record
ord-b742c408adf44ec58e4fd583a05b8d71
Source dataset
uspto-grants-2001_11
Patent number
US06313145B1

Reaction notes

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