6-(Trifluoromethyl)indoline → 1-[2-(Pyridin-2-ylmethyloxy)pyridin-5ylcarbamoyl]-6-trifluoromethyl-indoline

HRID 427739Notes

Reaction equation

HRID 427739 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:24])OC2C=CC=CC=2)=[CH:11][N:10]=1.[F:25][C:26]([F:37])([F:36])[C:27]1[CH:35]=[C:34]2[C:30]([CH2:31][CH2:32][NH:33]2)=[CH:29][CH:28]=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([N:33]2[C:34]3[C:30](=[CH:29][CH:28]=[C:27]([C:26]([F:25])([F:36])[F:37])[CH:35]=3)[CH2:31][CH2:32]2)=[O:24])=[CH:11][N:10]=1

Participants

3

Reactant 2

HCID 101764376-(Trifluoromethyl)indolineHCID 11141770Phenyl N-[2-(pyridin-2-ylmethyloxy)pyridin-5-yl]carbamate

Product 1

HCID 183577241-[2-(Pyridin-2-ylmethyloxy)pyridin-5ylcarbamoyl]-6-trifluoromethyl-indoline

Procedure

Phenyl N-[2-(pyridin-2-ylmethyloxy)pyridin-5-yl]carbamate (D3) and 6-trifluoromethylindoline (WO 96/23783) were converted into the title compound using a method similar to that of Example 1, m.p. 178-179° C.

Sources & evidence

ORD record
ord-2214641fc5e04914b17eb86118a03c30
Source dataset
uspto-grants-2001_11
Patent number
US06313145B1

Reaction notes

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