Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 427739Generated: October 29, 2026

6-(Trifluoromethyl)indoline → 1-[2-(Pyridin-2-ylmethyloxy)pyridin-5ylcarbamoyl]-6-trifluoromethyl-indoline

https://huagongshe.com/reaction/427739

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(Trifluoromethyl)indolineHCID 10176437—
ReactantPhenyl N-[2-(pyridin-2-ylmethyloxy)pyridin-5-yl]carbamateHCID 11141770—
Product1-[2-(Pyridin-2-ylmethyloxy)pyridin-5ylcarbamoyl]-6-trifluoromethyl-indolineHCID 18357724—

Reaction Steps

Phenyl N-[2-(pyridin-2-ylmethyloxy)pyridin-5-yl]carbamate (D3) and 6-trifluoromethylindoline (WO 96/23783) were converted into the title compound using a method similar to that of Example 1, m.p. 178-179° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06313145B1
Source datasetuspto-grants-2001_11
ORD IDord-2214641fc5e04914b17eb86118a03c30
Source noteuspto-grants-2001_11