反应详情

2-[N-(5-Bromo-2-hydroxybenzyl)-N-ethylamino]pyridine-5-carboxylic acid (example 7) (1.8 g, 5.1 mmol) in tetrahydrofuran (40 ml) treated with carbonyl diimidazole (1.8 g, 11 mmol) and heated at gentle reflux for 4 hours. The mixture was cooled and added to 0.88 aqueous ammonia solution (60 ml), stirred for 1 hour at ambient temperature and then evaporated to low bulk. The resultant white solid was diluted with ice/water, filtered, washed with cold water and air dried to give the title compound as a white solid (1.93 g, 100%).

1. temperatureheated
2. temperatureat gentle reflux for 4 hours
3. temperatureThe mixture was cooled
4. customevaporated to low bulk
5. additionThe resultant white solid was diluted with ice/water
6. filtrationfiltered
7. washwashed with cold water and air
8. customdried