Potassium Carbonate → HCID 22568938, compound

HRID 427899Notes

Reaction equation

HRID 427899 reaction equation
[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[C:14][Si](C)(C)C)=[CH:9][C:8]=2[CH:19]([CH3:21])[CH3:20])[CH2:6][CH2:5]1)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[CH:14])=[CH:9][C:8]=2[CH:19]([CH3:20])[CH3:21])[CH2:6][CH2:5]1)[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22569012[4-(1-Ethoxycyclopropyl)-3-isopropyl-phenylethynyl]-trimethylsilane2×

Product 1

HCID 22568938HCID 22568938, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-ethoxycyclopropyl)-3-isopropyl-phenylethynyl]-trimethylsilane (Intermediate 102, 210.0 mg, 0.70 mmol) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne was used directly in the next reaction.

Sources & evidence

ORD record
ord-79351509eb8147919dd36b5d2dbd65cf
Source dataset
uspto-grants-2001_11
Patent number
US06313107B1

Reaction notes

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