(3-Bromophenyl)acetic acid → 2-[(3-bromophenyl)acetamido]butyric Acid isobutyl Ester

HRID 428088Notes

Reaction equation

HRID 428088 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 74653(3-Bromophenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 154817712-[(3-bromophenyl)acetamido]butyric Acid isobutyl Ester

Procedure

Following General Procedure I above and using 3-bromophenylacetic acid (Aldrich) and isobutyl 2-aminobutyrate (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-092cf1b115404b668cc306f33fca114d
Source dataset
uspto-grants-2001_11
Patent number
US06313152B1

Reaction notes

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