3-Methyl-2-buten-1-OL → HCID 54323857, compound

HRID 428095Notes

Reaction equation

HRID 428095 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([NH:11][C@H:12]([C:14]([OH:16])=[O:15])[CH3:13])=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH3:17][C:18]([CH3:22])=[CH:19][CH2:20]O>>[CH3:17][C:18]([CH3:22])=[CH:19][CH2:20][O:15][C:14](=[O:16])[C@H:12]([CH3:13])[NH:11][C:9](=[O:10])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1

Participants

3

Reactant 2

HCID 111733-Methyl-2-buten-1-OLHCID 15481783N-(3-chlorophenylacetyl)alanine

Product 1

HCID 54323857HCID 54323857, compound

Procedure

Following General Procedure C above and using N-(3-chlorophenylacetyl alanine (from Example D above) and 3-methylbut-2-en-1-ol (Aldrich), the title compound can be prepared. The reaction was monitored by tlc on silica gel and purification was by liquid chromatography using 30% EtOAc/hexane as the eluant.

Sources & evidence

ORD record
ord-5db82e2e084d48ddbca365735267f543
Source dataset
uspto-grants-2001_11
Patent number
US06313152B1

Reaction notes

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