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2,7-Dimethoxy-1-naphthaldehyde → 2-Hydroxy-7-methoxy-1-naphthaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,7-Dimethoxy-1-naphthaldehyde | HCID 293215 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Hydroxy-7-methoxy-1-naphthaldehyde | HCID 10536097 | — |
反応手順
After the dimethoxylated product obtained in Step B (2 g:9.25 mmol) has been dissolved in anhydrous dichloromethane, 97% BBr3Me2S complex (2.98 g:9.25 mmol:1 eq.) is introduced at ambient temperature. After 35 minutes of stirring, hydrolysis is carried out with a saturated solution of sodium hydrogen carbonate (pH=8). The product is extracted with dichloromethane and then purified on a silica column AcOEt/PE (3/7).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06313160B1 |
| 出典データセット | uspto-grants-2001_11 |
| ORD ID | ord-4b095e46f6eb4ea897f9a95701f82c92 |
| 出典メモ | uspto-grants-2001_11 |