Hydrochloric Acid → HCID 15391779, compound

Participants

Reaction Steps

2.18 g (10 mmol) of the aldehyde obtained in Step C are dissolved in 25 ml of anhydrous ethanol and then 0.38 g (10 mmol) of sodium borohydride is added to the medium. After 15 minutes of stirring, the solvent is evaporated in vacuo; the residue obtained is then acidified with a 1N hydrochloric acid solution. The aqueous phase is extracted with dichloromethane; the organic phase is then dried over magnesium sulphate and then concentrated under reduced pressure. The crude product is passed over a silica column (eluant:petroleum ether/ethyl acetate:70/30 then 50/50) to yield the title alcohol in the form of a clear syrup.

Provenance & Evidence