Triphenylphosphine dibromide → HCID 18177430, compound

HRID 428201Notes

Reaction equation

HRID 428201 reaction equation
[Br:1]P(Br)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[CH2:22]([O:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[O:34][CH2:33][C:32]([CH2:38]O)=[CH:31]2)[CH2:23][CH2:24][CH2:25][CH3:26]>C(#N)C.CCOCC.CCCCCC>[CH2:22]([O:27][C:28]1[CH:29]=[C:30]2[C:35](=[CH:36][CH:37]=1)[O:34][CH2:33][C:32]([CH2:38][Br:1])=[CH:31]2)[CH2:23][CH2:24][CH2:25][CH3:26]

Participants

5

Reactant 2

HCID 70579Triphenylphosphine dibromideHCID 18177458HCID 18177458, compound

Product 1

HCID 18177430HCID 18177430, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 21584099Diethylether hexaneSolvent

Procedure

2 g (4.7 mmol) of dibromotriphenylphosphorane are added to a solution of 1.15 g (4.6 nmnol) of the alcohol obtained in Step C in 25 ml of anhydrous acetonitrile. The medium is stirred for 1 hour at ambient temperature; the solvent is then evaporated in vacuo. The residue obtained is taken up in a mixture of ether/hexane (1/1); the solid formed is then filtered off over Celite. Evaporation of the filtrate yields the brominated compound of the title in the form of a chestnut-brown syrup.

Workup

  1. customthe solvent is then evaporated in vacuo
  2. customThe residue obtained
  3. customthe solid formed
  4. filtrationis then filtered off over Celite
  5. customEvaporation of the filtrate
  6. customyields the brominated compound of the title in the form of a chestnut-brown syrup

Sources & evidence

ORD record
ord-f51b1b9185f548f288d64a961657e508
Source dataset
uspto-grants-2001_11
Patent number
US06313160B1

Reaction notes

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