Methyl 4-iodosalicylate → HCID 18357889, compound

HRID 428211Notes

Reaction equation

HRID 428211 reaction equation
[C:1]([CH:3]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:8]([O:15][CH2:16][O:17][CH2:18][CH2:19][Si:20]([CH3:23])([CH3:22])[CH3:21])=[C:7]([C:24]([CH3:27])([CH3:26])[CH3:25])[CH:6]=1)[OH:4])#[CH:2].[OH:28][C:29]1[CH:38]=[C:37](I)[CH:36]=[CH:35][C:30]=1[C:31]([O:33][CH3:34])=[O:32]>>[OH:28][C:29]1[CH:38]=[C:37]([C:2]#[C:1][CH:3]([OH:4])[C:5]2[CH:6]=[C:7]([C:24]([CH3:27])([CH3:26])[CH3:25])[C:8]([O:15][CH2:16][O:17][CH2:18][CH2:19][Si:20]([CH3:21])([CH3:23])[CH3:22])=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=2)[CH:36]=[CH:35][C:30]=1[C:31]([O:33][CH3:34])=[O:32]

Participants

3

Reactant 2

HCID 11380407Methyl 4-iodosalicylateHCID 17867292HCID 17867292, compound

Product 1

HCID 18357889HCID 18357889, compound

Procedure

In a similar manner to Example 1(d), by reaction of 6.7 g (17.3 mmol) of α-ethynyl-3,5-di-tert-butyl-4-(2-trimethylsilylethoxymethoxy)benzenemethanol with 4.8 g (17.3 mmol) of methyl 2-hydroxy-4-iodobenzoate, 8.5 g (91%) of the expected ester are obtained in the form of a yellow oil.

Workup

  1. customare obtained in the form of a yellow oil

Sources & evidence

ORD record
ord-c807b75cacb448e282775794a1ba06d5
Source dataset
uspto-grants-2001_11
Patent number
US06313162B1

Reaction notes

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