Diethanolamine → HCID 18357932, compound

HRID 428217Notes

Reaction equation

HRID 428217 reaction equation
[OH:1][C:2]1[CH:10]=[C:9]([C:11]#[C:12][CH2:13][C:14]2[CH:23]=[CH:22][C:21]3[C:20]([CH3:25])([CH3:24])[CH2:19][CH2:18][C:17]([CH3:27])([CH3:26])[C:16]=3[CH:15]=2)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH:28]([CH2:32][CH2:33][OH:34])[CH2:29][CH2:30][OH:31]>CO>[OH:1][C:2]1[CH:10]=[C:9]([C:11]#[C:12][CH2:13][C:14]2[CH:23]=[CH:22][C:21]3[C:20]([CH3:25])([CH3:24])[CH2:19][CH2:18][C:17]([CH3:27])([CH3:26])[C:16]=3[CH:15]=2)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[NH:28]([CH2:32][CH2:33][OH:34])[CH2:29][CH2:30][OH:31]

Participants

4

Reactant 2

HCID 8113DiethanolamineHCID 15389071HCID 15389071, compound

Product 1

HCID 18357932HCID 18357932, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

100 mg (2.76 mmol) of 2-hydroxy-4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propynyl]benzoic acid and 5 ml of methanol are introduced into a round-bottomed flask and 29 mg (2.76 mmol) of diethanolamine are added. The reaction medium is stirred for one hour and evaporated to dryness, and the residue obtained is triturated from a mixture of heptane and ethyl ether (50/50). The solid is filtered off and dried. 100 mg (78%) of diethanolamine salt are collected, with a melting point of 100-5° C.

Workup

  1. customevaporated to dryness
  2. customthe residue obtained
  3. customis triturated from a mixture of heptane and ethyl ether (50/50)
  4. filtrationThe solid is filtered off
  5. customdried
  6. custom100 mg (78%) of diethanolamine salt are collected, with a melting point of 100-5° C.

Sources & evidence

ORD record
ord-626ce677701b427c834445c8b119297e
Source dataset
uspto-grants-2001_11
Patent number
US06313162B1

Reaction notes

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