Dimethyl 3'-ethoxy-3-nitrobiphenyl-4-malonate → 3'-Ethoxy-3-nitrobiphenyl-4-acetic acid

HRID 428281Notes

Reaction equation

HRID 428281 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([CH:16](C(OC)=O)[C:17]([O:19]C)=[O:18])=[C:12]([N+:25]([O-:27])=[O:26])[CH:11]=2)[CH:7]=[CH:8][CH:9]=1)[CH3:2]>Cl>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=[O:18])=[C:12]([N+:25]([O-:27])=[O:26])[CH:11]=2)[CH:7]=[CH:8][CH:9]=1)[CH3:2]

Participants

3

Reactant 1

HCID 10714380Dimethyl 3'-ethoxy-3-nitrobiphenyl-4-malonate

Product 1

HCID 107806283'-Ethoxy-3-nitrobiphenyl-4-acetic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Crude dimethyl 3′-ethoxy-3-nitrobiphenyl-4-malonate was heated at 100° C. in 60 mL of 6N hydrochloric acid for 4 days and then cooled. The precipitate was collected by filtration, washed with water and hexane, and dried to give 4.7 g of crude 3′-ethoxy-3-nitrobiphenyl-4-acetic acid as a light tan solid.

Workup

  1. temperaturecooled
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water and hexane
  4. customdried

Sources & evidence

ORD record
ord-92e7b6804c4342d59f50da8d3781d680
Source dataset
uspto-grants-2001_11
Patent number
US06313158B1

Reaction notes

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