Hydroxyamine hydrochloride → HCID 86204337, compound

HRID 428295Notes

Reaction equation

HRID 428295 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[CH:22]=[CH:21][C:12]([C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=O)=[CH:11][CH:10]=1.Cl.[NH2:24][OH:25].C([O-])(=O)C.[Na+]>C(O)C>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[CH:22]=[CH:21][C:12]([C:13](=[N:24][OH:25])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 11737779{4-[(2-Aminophenyl)amino]phenyl}(Phenyl)methanone2×

Product 1

HCID 86204337HCID 86204337, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-(2-aminophenylamino)benzophenone (compound 101, 0.58 g, 2 mmol) and hydroxylamine hydrochloride (0.42 g, 6 mmol) in ethanol (30 ml) was added sodium acetate (0.49 g, 6 mmol). The reaction mixture was refluxed for 30 hours, cooled to room temperature, filtered, and evaporated in vacuo. The residue was treated with water (10 ml) and diluted ammonium hydroxide (5 ml). The precipitate that forms was filtered off, washed with water and dried to afford the title compound.

Workup

  1. temperatureThe reaction mixture was refluxed for 30 hours
  2. filtrationfiltered
  3. customevaporated in vacuo
  4. additionThe residue was treated with water (10 ml) and diluted ammonium hydroxide (5 ml)
  5. filtrationThe precipitate that forms was filtered off
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-8333495f552c49b7a5980668bd9a1613
Source dataset
uspto-grants-2001_11
Patent number
US06313174B1

Reaction notes

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