HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetic Acid → 1-(phenylacetyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetic Acid | HCID 999 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Hexamethyldisilazane | HCID 13838 | — |
| Product | 1-(phenylacetyl)piperazine | HCID 2873918 | 82.2% |
Reaction Steps
The procedures of Example 1 were followed except that phenyl acetic acid (3.4 grams, 25 mmole), piperazine (4.3 grams, 50 mmole) and 1,1,1,3,3,3-hexamethyldisilazane (4.0 grams, 25 mmole) were reacted for 5 hours under 110° C. After extraction purification, 4.2 grams of Compound 10 was obtained. Yield: 82%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313293B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-38dfa37920e9453ba176d781797068e3 |
| Source note | uspto-grants-2001_11 |