Phenylacetic Acid → 1-(phenylacetyl)piperazine

HRID 428359Notes

Reaction equation

HRID 428359 reaction equation
[C:1]1([CH2:7][C:8]([OH:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.C[Si](C)(C)N[Si](C)(C)C>>[CH2:7]([C:8]([N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)=[O:10])[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 999Phenylacetic AcidHCID 4837PiperazineHCID 13838Hexamethyldisilazane

Product 1

HCID 28739181-(phenylacetyl)piperazineYield 82.2%

Procedure

The procedures of Example 1 were followed except that phenyl acetic acid (3.4 grams, 25 mmole), piperazine (4.3 grams, 50 mmole) and 1,1,1,3,3,3-hexamethyldisilazane (4.0 grams, 25 mmole) were reacted for 5 hours under 110° C. After extraction purification, 4.2 grams of Compound 10 was obtained. Yield: 82%.

Workup

  1. customwere reacted for 5 hours under 110° C
  2. extractionAfter extraction purification

Sources & evidence

ORD record
ord-38dfa37920e9453ba176d781797068e3
Source dataset
uspto-grants-2001_11
Patent number
US06313293B1

Reaction notes

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