Styrene → HCID 3798589, compound

HRID 428366Notes

Reaction equation

HRID 428366 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH2:14]=[CH:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[Li]CCCC>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 7501StyreneHCID 752601-(4-Fluorophenyl)piperazineHCID 178418339Butyllithium

Product 1

HCID 3798589HCID 3798589, compound

Procedure

According to GP, 2.22 mmol (=0.40 g) of 1-(4-fluorophenyl)piperazine and 2.22 mmol (=0.23 g=0.25 ml) of styrene are reacted with 5 mol % (=0.111 mmol=70 μl) of n-BuLi solution. Column-chromatographic separation with ethyl acetate/n-hexane (3:1) gives the product 1-(4-fluorophenyl)-4-(2-phenyl-1-ethyl)piperazine as a light-brown solid.

Workup

  1. customColumn-chromatographic separation with ethyl acetate/n-hexane (3:1)

Sources & evidence

ORD record
ord-4f7c1096a7184a6d922033d5d067aaa4
Source dataset
uspto-grants-2001_11
Patent number
US06313297B1

Reaction notes

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