Trifluoroacetic acid → HCID 178525254, compound

HRID 428447Notes

Reaction equation

HRID 428447 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]2[C:6](=[O:23])[C:7]3[C:14]([CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])=[N:13][NH:12][C:8]=3[C:9](=[O:11])[NH:10][C:4]=2[CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]2[C:6](=[O:23])[C:7]3[C:14]([CH2:15][C:16]([OH:18])=[O:17])=[N:13][NH:12][C:8]=3[C:9](=[O:11])[NH:10][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178450903HCID 178450903, compound

Product 1

HCID 178525254HCID 178525254, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of 7-chloro-3-((t-butoxy)carbonylmethyl)pyrazolo[3,4-c][1]benzazepine-4,10(1H,9H)-dione (0.26 g, 0.72 mmol) in methylene chloride (6 mL) was added trifluoroacetic acid (6.38 g, 56 mmol) via syringe. The reaction was stirred at room temperature for 30 minutes. The reaction mixture was concentrated via rotary evaporator to give a solid which was recrystallized from dimethylformamide and dried at 100° C. to yield the title compound (0.14 g, 64%, mp 297.3-299.6° C.).

Workup

  1. concentrationThe reaction mixture was concentrated via rotary evaporator
  2. customto give a solid which
  3. customwas recrystallized from dimethylformamide
  4. customdried at 100° C.

Sources & evidence

ORD record
ord-5ad2ed68801d459fb2bad4912f48da3c
Source dataset
uspto-grants-2001_11
Patent number
US06313290B1

Reaction notes

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