反应详情

1-(2,4-difluorophenyl)-6,7-difluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, 120 mg of t-butyl 8-(methoxyimino)-2,6-diazaspiro[3,4]octane-2-carboxylate and 400 mg of Amberlite® IRA-420 were added to 10 ml of acetonitrile and thereto 0.5 ml of triethylamine was added by dropping. The resulting mixture was refluxed for 48 hours and thus precipitated solid was filtered off. To the filtrate 5 ml of ethylether was added and the resulting mixture was stirred for 4 hours. The precipitated solid was filtered and dried to give 110 mg of the titled compound(yield: 67.8%).

1. temperatureThe resulting mixture was refluxed for 48 hours
2. filtrationthus precipitated solid was filtered off
3. additionTo the filtrate 5 ml of ethylether was added
4. filtrationThe precipitated solid was filtered
5. customdried