反应详情

150 mg of 7-[2-(t-butoxycarbonyl)-8-(methoxyimino)-2.6-diazaspiro[3,4]oct-6-yl]-1-cyclopropyl-6,8-difluoro-4-oxo-1.4-dihydro-3-quinolinecarboxylic acid was dissolved in 5 ml of dichloromethane and thereto 1 ml of trifluoroacetic acid was added dropwise. The mixture was stirred for 5 hours at room temperature and thereto 10 ml of ethylether was added. It was additionally stirred for 1 hour, and thus precipitated solid was filtered and dried. Thus obtained solid was dissolved in 5 ml of diluted sodium hydroxide and neutralized with diluted hydrochloric acid. The resulting precipitate was filtered and dried to give 115 mg of the titled compound(yield: 87.4%).

1. stirringIt was additionally stirred for 1 hour
2. filtrationthus precipitated solid was filtered
3. customdried
4. dissolutionThus obtained solid was dissolved in 5 ml of diluted sodium hydroxide and neutralized with diluted hydrochloric acid
5. filtrationThe resulting precipitate was filtered
6. customdried