6-Fluoroindole → 3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-6-fluoro-1H-indole

HRID 428484Notes

Reaction equation

HRID 428484 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[NH:13][CH:12]=3)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[F:20]C1C=C2C(C=CN2)=CC=1>>[O:4]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][C:16]([F:20])=[CH:17][CH:18]=4)[NH:13][CH:12]=3)=[CH:7][CH2:6]2)[O:1][CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 3512786-FluoroindoleHCID 27638573-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole

Product 1

HCID 184141663-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-6-fluoro-1H-indoleYield 96.3%

Procedure

This compound was prepared in the manner described for intermediate 1a by replacing indole with 6-fluoroindole (5.14 g, 38 mmol) ) to afford 10 g (96.3%) of the title compound as a white solid: mp 196-197° C.

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-073920222edc4c1988928536db1edb8e
Source dataset
uspto-grants-2001_11
Patent number
US06313126B1

Reaction notes

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