Indole → 3-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-5-methoxy-1H-indole

HRID 428488Notes

Reaction equation

HRID 428488 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[NH:13][CH:12]=3)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.N1C2C(=CC=CC=2)C=C1.[CH3:29][O:30]C1NC2C(C=1)=CC=CC=2>>[O:4]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[C:19]4[C:14](=[CH:15][CH:16]=[C:17]([O:30][CH3:29])[CH:18]=4)[NH:13][CH:12]=3)=[CH:7][CH2:6]2)[O:1][CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 798IndoleHCID 27638573-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-1H-indoleHCID 17763644HCID 17763644, compound

Product 1

HCID 27640863-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)-5-methoxy-1H-indoleYield 82%

Procedure

This compound was prepared in the manner described above for intermediate 1a by replacing indole with 5 methoxy indole (5 g, 34 mmol) in 82% yield (7.95 g) as a white solid: mp 161-162° C.

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-d2ba9c68570445359820d5239c3fc788
Source dataset
uspto-grants-2001_11
Patent number
US06313126B1

Reaction notes

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