4-(1H-Indol-3-YL)cyclohexanone → 4-(2-Methyl-1H-3-indolyl)-cyclohexanone

HRID 428504Notes

Reaction equation

HRID 428504 reaction equation
N1C2C(=CC=CC=2)C(C2CCC(=O)CC2)=C1.O1[C:21]2([CH2:26][CH2:25][CH:24]([C:27]3[C:35]4[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=4)[NH:29][C:28]=3[CH3:36])[CH2:23][CH2:22]2)[O:20]CC1>>[CH3:36][C:28]1[NH:29][C:30]2[C:35]([C:27]=1[CH:24]1[CH2:25][CH2:26][C:21](=[O:20])[CH2:22][CH2:23]1)=[CH:34][CH:33]=[CH:32][CH:31]=2

Participants

3

Reactant 2

HCID 108462644-(1H-Indol-3-YL)cyclohexanoneHCID 184140993-(1,4-dioxa-spiro[4,5]dec-8-yl)-2-methyl-1H-indole

Product 1

HCID 184140564-(2-Methyl-1H-3-indolyl)-cyclohexanoneYield 88%

Procedure

This compound was prepared in the manner described above for intermediate 3a by replacing 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-1H-indole with 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-2-methyl-1H-indole (2.2 g) to afford 1.62 g (88%) of the title compound as a yellow thick oil: MS EI m/e 227 (M+).

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-f89c8bdc5383465789076d38b682a162
Source dataset
uspto-grants-2001_11
Patent number
US06313126B1

Reaction notes

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