4-(1H-Indol-3-YL)cyclohexanone → 4-(1H-Pyrrolo[2,3-B]pyridin-3-YL)cyclohexanone

HRID 428505Notes

Reaction equation

HRID 428505 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7]C=2)[C:3]([CH:10]2[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]2)=[CH:2]1.O1C2(CCC(C3C4C(=CC=CC=4)N[N:28]=3)CC2)OCC1>>[NH:1]1[C:9]2=[N:28][CH:7]=[CH:6][CH:5]=[C:4]2[C:3]([CH:10]2[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]2)=[CH:2]1

Participants

3

Reactant 2

HCID 108462644-(1H-Indol-3-YL)cyclohexanoneHCID 178419917HCID 178419917, compound

Product 1

HCID 184141064-(1H-Pyrrolo[2,3-B]pyridin-3-YL)cyclohexanoneYield 95%

Procedure

This compound was prepared in the manner described above for intermediate 3a by replacing 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-1H-indole with 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-1H-azaindole (2.48 g) to afford 1.96 g (95%) of the title compound as a white solid: mp 162-164° C.

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-f8361e3bad294f1fa893a17f8e730bd4
Source dataset
uspto-grants-2001_11
Patent number
US06313126B1

Reaction notes

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