反应详情

A mixture of 1-benzyl-4-(5-fluoro-2,3-dihydro-benzofuran-7-yl)-piperazine (2.06 g, 6.6 mmol), 10% palladium on carbon (0.6 g) and ammonium formate (0.83 g, 13 mmol) in ethanol (20 ml) was allowed to refux for 2 hours. The catalyst was filtered off and the solvent removed under vacuum. Chromatography (10-30% methanol-methylene chloride plus ammonium hydroxide) afforded 1.10 g (75%) of product as a yellow oil; MS EI m/e 222 (M)+.

1. filtrationThe catalyst was filtered off
2. customthe solvent removed under vacuum