3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole → 4-(5-Fluoro-1H-3-indolyl)-cyclohex-3-enone

HRID 428524Notes

Reaction equation

HRID 428524 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH2:12]1.C1OC2(CCC(C3C4C(=CC=C(F)C=4)NC=3)=CC2)OC1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]1[CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH:12]=1

Participants

3

Reactant 2

HCID 105163803-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indoleHCID 107046834-(5-Fluoro-1H-indol-3-YL)cyclohexanone

Product 1

HCID 184140964-(5-Fluoro-1H-3-indolyl)-cyclohex-3-enoneYield 88%

Procedure

This compound was prepared in the manner described above for intermediate 3c by replacing 4-(5-fluoro-1H-3-indolyl)-cyclohexanone ethylene ketal with 4-(5-fluoro-1H-3-indolyl)-cyclohex-3-enone-ethylene ketal (1.37 g) to afford 1.01 g (88%) of the title compound.

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-f10ec17f958046f4a34fb740eeecddc9
Source dataset
uspto-grants-2001_11
Patent number
US06313126B1

Reaction notes

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