Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 428524Generated: October 25, 2026

3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indole → 4-(5-Fluoro-1H-3-indolyl)-cyclohex-3-enone

https://huagongshe.com/reaction/428524

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(1,4-Dioxa-spiro[4,5]dec-7-en-8-yl)-5-fluoro-1H-indoleHCID 10516380—
Reactant4-(5-Fluoro-1H-indol-3-YL)cyclohexanoneHCID 10704683—
Product4-(5-Fluoro-1H-3-indolyl)-cyclohex-3-enoneHCID 1841409688%

Reaction Steps

This compound was prepared in the manner described above for intermediate 3c by replacing 4-(5-fluoro-1H-3-indolyl)-cyclohexanone ethylene ketal with 4-(5-fluoro-1H-3-indolyl)-cyclohex-3-enone-ethylene ketal (1.37 g) to afford 1.01 g (88%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06313126B1
Source datasetuspto-grants-2001_11
ORD IDord-f10ec17f958046f4a34fb740eeecddc9
Source noteuspto-grants-2001_11