4-(1H-Indol-3-YL)cyclohexanone → 4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-cyclohexanone

HRID 428526Notes

Reaction equation

HRID 428526 reaction equation
N1C2C(=CC=CC=2)C(C2CCC(=O)CC2)=C1.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:30][CH2:29][N:28]([CH:31]2[CH2:40][CH2:39][C:34]3(OCC[O:35]3)[CH2:33][CH2:32]2)[CH2:27][CH2:26]1>>[CH3:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:30][CH2:29][N:28]([CH:31]2[CH2:40][CH2:39][C:34](=[O:35])[CH2:33][CH2:32]2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 108462644-(1H-Indol-3-YL)cyclohexanoneHCID 110020981-(2-Methoxy-phenyl)4-(1,4-dioxa-spiro[4,5]dec-8-yl)-piperazine

Product 1

HCID 105653074-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-cyclohexanoneYield 93%

Procedure

This compound was prepared in the manner described above for intermediate 3a by replacing 3-(1,4-dioxa-spiro[4,5]dec-8-yl)-1H-indole with 1-(2-methoxy-phenyl)-4-(1,4-dioxa-spiro[4,5]dec-8-yl)-piperazine (5.0 g, 15 mmol) to afford 4.0 g (93%) of the title compound.

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-6654b02fe8db4c36ae2ab466c091fc0d
Source dataset
uspto-grants-2001_11
Patent number
US06313126B1

Reaction notes

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