Triethylamine → HCID 18004891, compound

HRID 428578Notes

Reaction equation

HRID 428578 reaction equation
Cl.[S:2]([N:6]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:8]2([CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH2:7]1)(=[O:5])(=[O:4])[NH2:3].[C:20]([C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:30](=O)[O:31]C2C=CC=CC=2)=[CH:25][CH:24]=1)(=[O:22])[CH3:21].CCN(CC)CC>>[C:20]([C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:30]([N:11]2[CH2:12][CH2:13][C:8]3([C:14]4[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=4)[N:6]([S:2](=[O:4])(=[O:5])[NH2:3])[CH2:7]3)[CH2:9][CH2:10]2)=[O:31])=[CH:25][CH:24]=1)(=[O:22])[CH3:21]

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 80600999134-77-7HCID 18004930HCID 18004930, compound

Product 1

HCID 18004891HCID 18004891, compoundYield 33.2%

Procedure

To a suspension of 1-sulfamoylspiro[indoline-3,4′-piperidine] hydrochloride 3-1 (100 mg, 0.33 mmol) and phenyl 4-acetylphenylcarbamate 3-2 (92 mg, 0.36 mmol) in CHCL3 (3 mL) was added Et3N (0.23 mL, 1.65 mmol) at room temperature. The reaction mixture was heated to reflux for 1 h. The resulting suspension was cooled to room temperature. The resulting suspension was filtered and the filter cake was washed with CHCl3 to give 300 (47 mg, 33%) as a white solid.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 1 h
  3. filtrationThe resulting suspension was filtered
  4. washthe filter cake was washed with CHCl3

Sources & evidence

ORD record
ord-48cb87dd24a1417faf083b5894c09fad
Source dataset
uspto-grants-2001_11
Patent number
US06313298B1

Reaction notes

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