反应详情

温度

50 °C

A mixture of methyl 3-fluoro-4-nitrobenzoate(2.14 g, 10.8 mmol) and iron powder(2.63 g) in acetic acid(22 ml) was stirred at 50° C. for 2.5 h. After cooling down to room temperature, CH2Cl2(100 ml) and water(300 ml) was added to the mixture and filtered to remove iron powder. The organic layer was separated and the aqueous layer was extracted with CH2Cl2(70 mlx2). The CH2Cl2 solution was combined, washed with water, brine, dried(Na2SO4), and concentrated to give 1.77 g(97%) of pale brown solid.

1. temperatureAfter cooling down to room temperature
2. filtrationfiltered
3. customto remove iron powder
4. customThe organic layer was separated
5. extractionthe aqueous layer was extracted with CH2Cl2(70 mlx2)
6. washwashed with water, brine, dried(Na2SO4)
7. concentrationconcentrated