HCID 53998100, compound → HCID 178467693, compound

HRID 428609Notes

Reaction equation

HRID 428609 reaction equation
C([N:8]1[C:12]([C:13]([OH:23])([CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH3:14])=[CH:11][N:10]=[CH:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[NH:10]1[CH:11]=[C:12]([C:13]([OH:23])([CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH3:14])[N:8]=[CH:9]1

Participants

4

Reactant 1

HCID 53998100HCID 53998100, compound

Product 1

HCID 178467693HCID 178467693, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3.3 g of 2-(3-benzyl-3H-imidazol-4-yl)-4-phenylbutan-2-ol is dissolved in 100 ml of ethanol. The reaction solution is hydrogenated at 50° C. with 10% palladium on carbon as catalyst for 4.5 hours. Work-up of the reaction mixture gives the crude product, which is recrystallized from ethyl acetate. The yield is 2.0 g.

Sources & evidence

ORD record
ord-8192b4dface748fc8d0622e2a3357103
Source dataset
uspto-grants-2001_11
Patent number
US06313311B1

Reaction notes

Loading…