Water → HCID 178519270, compound

HRID 428634Notes

Reaction equation

HRID 428634 reaction equation
[BH4-].[Na+].[OH:3][C:4]1[CH:12]=[C:11]2[C:7]([CH:8]([CH2:13][C:14]3[N:15]=[CH:16][NH:17][CH:18]=3)[CH2:9][CH2:10]2)=[CH:6][C:5]=1[CH:19]=[O:20].O>C(O)C>[OH:20][CH2:19][C:5]1[CH:6]=[C:7]2[C:11]([CH2:10][CH2:9][CH:8]2[CH2:13][C:14]2[N:15]=[CH:16][NH:17][CH:18]=2)=[CH:12][C:4]=1[OH:3]

Participants

5

Reactant 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 178519269HCID 178519269, compound

Product 1

HCID 178519270HCID 178519270, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium borohydride (10 mg) is added into a solution of 6-hydroxy-3-(1H-imidazol-4-ylmethyl)-indan-5-carbaldehyde (58 mg) in ethanol (10 ml). The mixture is stirred at room temperature for one hour and then poured into water. Work-up of the mixture gives the crude product which is purified by flash chromatography and recrystallized from ethyl acetate.

Sources & evidence

ORD record
ord-5ff23d2c97ea4d1f970527d9a842914c
Source dataset
uspto-grants-2001_11
Patent number
US06313311B1

Reaction notes

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