HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyridinecarboxaldehyde → 2-Pyridinemethanol,alpha-ethynyl-(9CI)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyridinecarboxaldehyde | HCID 14273 | — |
| Reactant | HCID 178462451 | HCID 178462451 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Pyridinemethanol,alpha-ethynyl-(9CI) | HCID 22730957 | — |
Reaction Steps
3-Hydroxy-3-(2-pyridinyl)-1-propyne was prepared according to Method A above from 2-pyridine carboxaldehyde (1.0 g, 9.3 mmol) (Aldrich) in THF (50 mL) and ethynylmagnesium chloride (10 mmol, 20 mL, 0.5M solution in tetrahydrofuran) (Aldrich). (Yield 956 mg, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313310B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-0fa3d6e8bc094339aa54b03e713f7bf5 |
| Source note | uspto-grants-2001_11 |