2-Pyridinecarboxaldehyde → 2-Pyridinemethanol,alpha-ethynyl-(9CI)
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[O:8].[C:9]([Mg]Cl)#[CH:10]>C1COCC1>[OH:8][CH:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:9]#[CH:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3-Hydroxy-3-(2-pyridinyl)-1-propyne was prepared according to Method A above from 2-pyridine carboxaldehyde (1.0 g, 9.3 mmol) (Aldrich) in THF (50 mL) and ethynylmagnesium chloride (10 mmol, 20 mL, 0.5M solution in tetrahydrofuran) (Aldrich). (Yield 956 mg, 77%).
Sources & evidence
- ORD record
- ord-0fa3d6e8bc094339aa54b03e713f7bf5
- Source dataset
- uspto-grants-2001_11
- Patent number
- US06313310B1
Reaction notes
Loading…