Methylamine → HCID 131722975, compound

HRID 428813Notes

Reaction equation

HRID 428813 reaction equation
[CH3:1][NH2:2].CO[C:5](=[O:44])[C:6]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][O:17][N:18]=[C:19]([CH3:43])[C:20](=[N:39][O:40][CH2:41][CH3:42])[C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][Si:29]([CH3:38])([CH3:37])[C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)=[CH:23][CH:22]=1)=[N:7][O:8][CH3:9]>C(O)C.CO>[CH3:1][NH:2][C:5](=[O:44])[C:6]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][O:17][N:18]=[C:19]([CH3:43])[C:20](=[N:39][O:40][CH2:41][CH3:42])[C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][Si:29]([CH3:38])([CH3:37])[C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)=[CH:23][CH:22]=1)=[N:7][O:8][CH3:9]

Participants

5

Reactant 2

HCID 6329MethylamineHCID 131722976HCID 131722976, compound

Product 1

HCID 131722975HCID 131722975, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

3 ml of a 8M solution of methylamine in ethanol are added to 2.9 g of 2-[[[(1-methyl-2-(4-[{dimethyl-(4-fluorophenyl)-silyl}methoxy]phenyl)-[ethoxyimino]ethylidene) amino]oxy]-methyl]-α-(methoxyimino)-phenylacetic acid methyl ester in 30 ml of methanol and stirring is carried out for 2 days at room temperature. The reaction mixture is concentrated to dryness by evaporation. Recrystallisation of the residue from hexane yields the title compound having a melting point of 88-90° C. (compound 5.23).

Workup

  1. concentrationThe reaction mixture is concentrated to dryness by evaporation
  2. customRecrystallisation of the residue from hexane

Sources & evidence

ORD record
ord-2d0148b523be49dcab53279cd720d315
Source dataset
uspto-grants-2001_11
Patent number
US06313344B1

Reaction notes

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