反应详情

A mixture of 23.1 g of 3-bromo-4-hydroxy-5-methoxy benzaldehyde, 9.3 g of cuprous cyanide and 140 ml of dimethyl acetamide (DMA) was refluxed for 2 hours with stirring. After cooling, the mixture was poured over ice and extracted with an ethyl acetate—methanol mixture (90-10). The organic phase was washed and dried and the solvents were eliminated to obtain 18 g of crude product, which was used as is for the following step. It melted at 180° C.

1. temperaturewas refluxed for 2 hours
2. temperatureAfter cooling
3. additionthe mixture was poured over ice
4. extractionextracted with an ethyl acetate—methanol mixture (90-10)
5. washThe organic phase was washed
6. customdried