反应详情

Mesyl chloride (1.73 ml) was added dropwise to a solution of 3-hydroxy-2-methoxy-1-hexen-5-yne (2 g) and triethylamine (3.32 ml) in methylene chloride (20 ml) under ice-cooling over a period of 10 minutes. After being stirred for 48 hours at room temperature the mixture was washed successively with water, aqueous sodium bicarbonate solution, and brine, dried over magnesium sulfate, and evaporated in vacuo to give 3-mesyloxy-2-methoxy-1-hexen-5-yne (3.45 g).

1. temperaturecooling over a period of 10 minutes
2. washwas washed successively with water, aqueous sodium bicarbonate solution, and brine
3. dry with materialdried over magnesium sulfate
4. customevaporated in vacuo