Ethyl chloroformate → HCID 57018666, compound

HRID 429035Notes

Reaction equation

HRID 429035 reaction equation
[Cl:1]C(OCC)=O.[CH3:7][C:8]1[CH2:9][C:10]([CH2:23]N2CCOCC2)=[C:11]([CH2:15][O:16][N:17]=[CH:18][C:19]([O:21][CH3:22])=[O:20])[CH2:12][C:13]=1[CH3:14]>C1COCC1>[CH3:22][O:21][C:19](=[O:20])[CH:18]=[N:17][O:16][CH2:15][C:11]1[CH2:12][C:13]([CH3:14])=[C:8]([CH3:7])[CH2:9][C:10]=1[CH2:23][Cl:1]

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 57238313HCID 57238313, compound

Product 1

HCID 57018666HCID 57018666, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.4 ml of ethyl chloroformate are added to a solution of 2.3 g methyl (4,5-dimethyl-2-morpholin-4-ylmethylcyclohexa-1,4-dienyl)methoxyiminoacetate in 25 ml of THF. The mixture is now heated for 20 hours at 70°. After the mixture has been evaporated, the residue is chromatographed on silica gel (ether/hexane 1:2). This gives 1.5 g of crystals of the title compound of melting point 65-68°.

Workup

  1. temperatureThe mixture is now heated for 20 hours at 70°
  2. customAfter the mixture has been evaporated
  3. customthe residue is chromatographed on silica gel (ether/hexane 1:2)

Sources & evidence

ORD record
ord-b9e20a5519fe4c188f7d4435467d5c5f
Source dataset
uspto-grants-2001_11
Patent number
US06316389B1

Reaction notes

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