Ethyl chloroformate → HCID 57018666, compound

HRID 429036Notes

Reaction equation

HRID 429036 reaction equation
[Cl:1]C(OCC)=O.[CH3:7][O:8][C:9](=[O:31])[CH:10]=[N:11][O:12][CH2:13][C:14]1[CH2:19][C:18]([CH3:20])=[C:17]([CH3:21])[CH2:16][C:15]=1[CH2:22]N1CC(C)OC(C)C1>C1COCC1>[CH3:7][O:8][C:9](=[O:31])[CH:10]=[N:11][O:12][CH2:13][C:14]1[CH2:19][C:18]([CH3:20])=[C:17]([CH3:21])[CH2:16][C:15]=1[CH2:22][Cl:1]

Participants

4

Reactant 2

HCID 10928Ethyl chloroformateHCID 131722981HCID 131722981, compound

Product 1

HCID 57018666HCID 57018666, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.4 ml of ethyl chloroformate are added to a solution of 2.1 g of methyl[2-(2,6-dimethylmorpholin-4-ylmethyl)-4,5-dimethylcyclohexa-1,4-dienyl]methoxyiminoacetate in 25 ml of THF. The mixture is now heated for 20 hours at 70°. After the mixture has been evaporated, the residue is chromatographed on silica gel (ether/hexane 1:2). This gives 1.2 g of crystals of the title compound of melting point 65-68°.

Workup

  1. temperatureThe mixture is now heated for 20 hours at 70°
  2. customAfter the mixture has been evaporated
  3. customthe residue is chromatographed on silica gel (ether/hexane 1:2)

Sources & evidence

ORD record
ord-2cbd4762fde747c0bc255741ef4c549e
Source dataset
uspto-grants-2001_11
Patent number
US06316389B1

Reaction notes

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