反应详情

A solution of 4-(4-fluorophenyl)piperidine (360 mg, 2 mmol) and crotononitrile (0.33 mL, 4 mmol) in methanol (4 mL) was refluxed for five hours. The solvent was concentrated under vacuum and the residue triturated with hexane/diethyl ether to give the racemic title compound as a solid.

1. concentrationThe solvent was concentrated under vacuum
2. customthe residue triturated with hexane/diethyl ether