HuagongsheHuagongshe Chemistry Print Report · For research reference only
Crotononitrile → 3-[4-(4-Fluorophenyl)piperidin-1-yl]butanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Crotononitrile | HCID 637921 | — |
| Reactant | 4-(4-Fluorophenyl)piperidine | HCID 2759136 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-[4-(4-Fluorophenyl)piperidin-1-yl]butanenitrile | HCID 91182868 | — |
Reaction Steps
A solution of 4-(4-fluorophenyl)piperidine (360 mg, 2 mmol) and crotononitrile (0.33 mL, 4 mmol) in methanol (4 mL) was refluxed for five hours. The solvent was concentrated under vacuum and the residue triturated with hexane/diethyl ether to give the racemic title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06316437B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-cb57cbf5692a4e1398d8d1901628f803 |
| Source note | uspto-grants-2001_11 |