HCID 21925692, compound → HCID 21925676, compound

HRID 429122Notes

Reaction equation

HRID 429122 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][C:17](=[O:22])[C:18]([F:21])([F:20])[F:19])[CH:11]=2)[CH:7]=[CH:6][C:5]=1[CH:23](C(OC)=O)[C:24]([O:26]C)=[O:25])([O-:3])=[O:2]>Cl>[N+:1]([C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][C:17](=[O:22])[C:18]([F:19])([F:20])[F:21])[CH:11]=2)[CH:7]=[CH:6][C:5]=1[CH2:23][C:24]([OH:26])=[O:25])([O-:3])=[O:2]

Participants

3

Reactant 1

HCID 21925692HCID 21925692, compound

Product 1

HCID 21925676HCID 21925676, compoundYield 73.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Dimethyl 2-[2-nitro-4-(3-trifluoroacetamidophenyl)phenyl]-malonate (4.4 g) was refluxed overnight in 50 mL 6N hydrochloric acid. The reaction mixture was cooled to room temperature and the solids were collected by vacuum filtration, washed with water, and dried under vacuum to give 2.7 g (73% yield) of 2-[2-nitro-4-(3-trifluoroacetamidophenyl)phenyl] acetic acid.

Workup

  1. filtrationthe solids were collected by vacuum filtration
  2. washwashed with water
  3. customdried under vacuum

Sources & evidence

ORD record
ord-3a652c2fd4694f09945428a34665fa7a
Source dataset
uspto-grants-2001_11
Patent number
US06316429B1

Reaction notes

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